12/14/2023 0 Comments Cobalt toxic![]() ![]() Systemic toxicity was first manifest months and often several years after placement of the metal-containing joint. The other eight had metal-on-metal prostheses. Ten of these eighteen patients had undergone revision from a ceramic-containing bearing to one containing a metal component. As some cases were reported repeatedly the 26 papers described only 18 individual cases. Three further reports were identified from the bibliographies of these papers. These searches identified 281 unique references, of which 23 contained original case data. Medline (from 1950) and Embase (from 1980) were searched to 28 February 2014 using the search terms (text/abstract) chrom* or cobalt* and and and PubMed (all available years) was searched using the search term (("Chromium/adverse effects" OR "Chromium/poisoning" OR "Chromium/toxicity") OR ("Cobalt/adverse effects" OR "Cobalt/poisoning" OR "Cobalt/toxicity")) AND ("Arthroplasty, Replacement, Hip" OR "Hip Prosthesis"). ![]() To identify and systematically review published reports of systemic toxicity attributed to metal released from hip implants and to propose criteria for the assessment of these patients. Friction between bearing surfaces and corrosion of non-moving parts can result in increased local and systemic metal concentrations. ![]() The bearing surfaces may be made of cobalt/chromium, stainless steel, ceramic, or polyethylene. One in eight of all total hip replacements requires revision within 10 years, 60% because of wear-related complications. ![]()
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